Synthesis of Novel -1, 3, 5 - Triazine - Based - Anti-Tuberculosis Drugs.

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dc.contributor.advisor Moleele, S. Mnyakeni
dc.contributor.advisor Ramaite, I. D. I.
dc.contributor.author Rapudi, Munaka
dc.date 2018
dc.date.accessioned 2018-10-06T07:11:20Z
dc.date.available 2018-10-06T07:11:20Z
dc.date.issued 2018-09-21
dc.identifier.citation Rapudi, Munaka (2018) Synthesis of Novel -1, 3, 5 - Triazine - Based - Anti-Tuberculosis Drugs, University of Venda, Thohoyandou, South Africa, <http://hdl.handle.net/11602/1231>
dc.identifier.uri http://hdl.handle.net/11602/1231
dc.description MSc (Chemistry)
dc.description Department of Chemistry
dc.description.abstract Identification of unique leads represents a significant challenge in drug discovery. This challenge is widely visible in neglected diseases such as tuberculosis, which is an infectious disease caused by bacillus Mycobacterium tuberculosis. The urgent need in search of new biological entities to fight back TB and drug resistant TB is a drive behind this project. Several specific synthetic protocols have been developed using 1,3,5-triazines due to the important biological properties which they display. The chemistry and an extensive spectrum of biological activities of s-triazines have been examined since several decades and this heterocyclic core has received emerging consensus. Hence, the aim of this project was to synthesize novel anti-TB drugs total with the usage of 1,3,5-triazine as a linker between known anti-TB drugs together with different types of amines. A total of 20 compounds were synthesized, 3 compounds were mono-substituted with an average yield of 75 %, 6 compounds were di-substituted with an average yield of 63 % and 11 compounds were tri-substituted with an average yield of 93 %. Out of 10 compounds which were analysed for biological activity 8 of which showed biological activity against M.smegmatis. Furthermore compound 26 which was hybridized with an amine and a known anti-TB drug inhibited better biological activity. In conclusion the influence of cyanuric chloride in combination with pyrrolidine and anti-TB drugs deserves further study. The newly synthesized compounds were characterized by IR, melting point, GC-MS, biological testing, 1H and 13C NMR. en_US
dc.description.sponsorship NRF en_US
dc.format.extent 1 online resource (v, 65 leaves ; illustrations)
dc.language.iso en en_US
dc.rights University of Venda
dc.subject Synthesis en_US
dc.subject Drugs en_US
dc.subject Novel en_US
dc.subject Triazine en_US
dc.subject Tuberculosis en_US
dc.subject.ddc 616.995
dc.subject.lcsh Tuberculosis
dc.subject.lcsh Tuberculosis -- Prevention
dc.subject.lcsh Tuberculosis -- Vaccination
dc.subject.lcsh Triazines
dc.subject.lcsh Communicable diseases infection
dc.subject.lcsh Terbtryn
dc.subject.lcsh Tuberculosis vaccines
dc.title Synthesis of Novel -1, 3, 5 - Triazine - Based - Anti-Tuberculosis Drugs. en_US
dc.type Dissertation en_US

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