Mnyakeni-Moleele, S. S.Ramaite, I. D. I.Mugwena, Dakalo Sandra2018-10-042018-10-042018-09-21Mugwena Dakalo Sandra (2018) Synthesis of 1, 3, 5 - Triazine Based Antimalarial Drugs. University of Venda, South Africa.<http://hdl.handle.net/11602/1193>.http://hdl.handle.net/11602/1193MSc (Chemistry)Department of ChemistryThis dissertation focuses on the application of 1, 3, 5-triazine in a pharmaceutical point of view since it has wide range of uses as described in chapter 1. Malaria is one of the most prevalent and deadly infectious diseases worldwide though there are already many synthesized anti-malarial drugs which are in use presently, drug resistance seems to be one of the major problem and combination therapy seems to be the only solution for now. Hence in this study we used hybridization as a tool (Figure 9) to synthesize new antimalarial drugs using 1, 3, 5-triazine as an intermediate linker, linking known anti-malarial drug, different amine and chloroquine-like amines together using nucleophilic substitution reaction. As explained in chapter four of this dissertation, triazine is used to synthesize mono-, di- and tri-amino-1, 3, 5-triazine substituted products. Using THF as a solvent and K2CO3 as a base changing in temperatures, from 0 oC 25 oC or reflux. Some products were synthesized using microwave irradiation. The application of triazine as an intermediate linker in the above mentioned condition yielded five mono-amino substituted dichloro-1, 3, 5-triazine (21-25) in an average yield of 82%, three amino substitution chloro-1, 3, 5-triazine (26-28) in an average yield of 87%, two amino substituted-1, 3, 5-triazine (29, 30) in an average of 90%, nine chloroquine-like synthesized compounds (33-41) in 84 % average yields respectively.1 online resource (vii, 69 leaves : color illustrations, color maps)enUniversity of VendaMalariaUCTDSynthesisDrugsTriazineAntimalarial614.532TriazinesAntimalarialsChloroquineMalaria -- ChemotherapyMalariaBacterial diseasesDissertationMugwena DS. Synthesis of 1, 3, 5 - Triazine Based Antimalarial Drugs. []. , 2018 [cited yyyy month dd]. Available from: http://hdl.handle.net/11602/1193Mugwena, D. S. (2018). <i>Synthesis of 1, 3, 5 - Triazine Based Antimalarial Drugs</i>. (). . Retrieved from http://hdl.handle.net/11602/1193Mugwena, Dakalo Sandra. <i>"Synthesis of 1, 3, 5 - Triazine Based Antimalarial Drugs."</i> ., , 2018. http://hdl.handle.net/11602/1193TY - Dissertation AU - Mugwena, Dakalo Sandra AB - This dissertation focuses on the application of 1, 3, 5-triazine in a pharmaceutical point of view since it has wide range of uses as described in chapter 1. Malaria is one of the most prevalent and deadly infectious diseases worldwide though there are already many synthesized anti-malarial drugs which are in use presently, drug resistance seems to be one of the major problem and combination therapy seems to be the only solution for now. Hence in this study we used hybridization as a tool (Figure 9) to synthesize new antimalarial drugs using 1, 3, 5-triazine as an intermediate linker, linking known anti-malarial drug, different amine and chloroquine-like amines together using nucleophilic substitution reaction. As explained in chapter four of this dissertation, triazine is used to synthesize mono-, di- and tri-amino-1, 3, 5-triazine substituted products. Using THF as a solvent and K2CO3 as a base changing in temperatures, from 0 oC 25 oC or reflux. Some products were synthesized using microwave irradiation. The application of triazine as an intermediate linker in the above mentioned condition yielded five mono-amino substituted dichloro-1, 3, 5-triazine (21-25) in an average yield of 82%, three amino substitution chloro-1, 3, 5-triazine (26-28) in an average yield of 87%, two amino substituted-1, 3, 5-triazine (29, 30) in an average of 90%, nine chloroquine-like synthesized compounds (33-41) in 84 % average yields respectively. DA - 2018-09-21 DB - ResearchSpace DP - Univen KW - Malaria KW - Synthesis KW - Drugs KW - Triazine KW - Antimalarial LK - https://univendspace.univen.ac.za PY - 2018 T1 - Synthesis of 1, 3, 5 - Triazine Based Antimalarial Drugs TI - Synthesis of 1, 3, 5 - Triazine Based Antimalarial Drugs UR - http://hdl.handle.net/11602/1193 ER -