Etta, Elizabeth M.Alayande, Doyinmola P.Mavhandu-Ramarumo, Lufuno G.Gachara, GeorgeBessong, Pascal O.2022-11-032022-11-032018-08-27Etta, Elizabeth M., Alayande, Doyinmola P., Mavhandu-Ramarumo, Lufuno G., Gachara, G. & Bessong, Pascal O. 2018. HHV-8 Seroprevalence and Genotype Distribution in Africa, 1998–2017: A Systematic Review. http://hdl.handle.net/11602/2318Doi:10.3390/v10090458http://hdl.handle.net/11602/2318Human herpes virus type 8 (HHV-8) is the causative agent of Kaposi’s sarcoma (KS). We systematically reviewed literature published between 1998 and 2017, according to the PRISMA guidelines, to understand the distribution of HHV-8 infection in Africa. More than two-thirds (64%) of studies reported on seroprevalence and 29.3% on genotypes; 9.5% were on both seroprevalence and genotypes. About 45% of African countries had data on HHV-8 seroprevalence exclusively, and more than half (53%) had data on either seroprevalence or genotypes. Almost half (47%) of the countries had no data on HHV-8 infection. There was high heterogeneity in the types of tests and interpretation algorithms used in determining HHV-8 seropositivity across the different studies. Generally, seroprevalence ranged from 2.0% in a group of young children in Eritrea to 100% in a small group of individuals with KS in Central African Republic, and in a larger group of individuals with KS in Morocco. Approximately 16% of studies reported on children. Difference in seroprevalence across the African regions was not significant (95% CI, 2 = 0.86; p = 0.35), although specifically a relatively significant level of infection was observed in HIV-infected children. About 38% of the countries had data on K1 genotypes. K1 genotypes A, A5, B, C, F and Z occurred at frequencies of 5.3%, 26.3%, 42.1%, 18.4%, 5.3% and 2.6%, respectively. Twenty-three percent of the countries had data for K15 genotypes, and genotypes P, M and N occurred at frequencies of 52.2%, 39.1%, and 8.7%, respectively. Data on HHV-8 inter-genotype recombinants in Africa are scanty. HHV-8 may be endemic in the entire Africa continent but there is need for a harmonized testing protocol for a better understanding of HHV-8 seropositivity. K1 genotypes A5 and B, and K15 genotypes P and M, from Africa, should be considered in vaccine design effortsenHHV-8UCTDSeroprevalenceGenotypesSystematic reviewAfricaArticleEtta Elizabeth M, Alayande Doyinmola P, Mavhandu-Ramarumo Lufuno G, Gachara G, Bessong Pascal O. HHV-8 Seroprevalence and Genotype Distribution in Africa, 1998–2017: A Systematic Review. 2018; http://hdl.handle.net/11602/2318.Etta, Elizabeth M., Alayande, Doyinmola P., Mavhandu-Ramarumo, Lufuno G., Gachara, G., & Bessong, Pascal O. (2018). HHV-8 Seroprevalence and Genotype Distribution in Africa, 1998–2017: A Systematic Review. http://hdl.handle.net/11602/2318Etta, Elizabeth M., Doyinmola P. Alayande, Lufuno G. Mavhandu-Ramarumo, George Gachara, and Pascal O. Bessong "HHV-8 Seroprevalence and Genotype Distribution in Africa, 1998–2017: A Systematic Review." (2018) http://hdl.handle.net/11602/2318TY - Article AU - Etta, Elizabeth M. AU - Alayande, Doyinmola P. AU - Mavhandu-Ramarumo, Lufuno G. AU - Gachara, George AU - Bessong, Pascal O. AB - Human herpes virus type 8 (HHV-8) is the causative agent of Kaposi’s sarcoma (KS). We systematically reviewed literature published between 1998 and 2017, according to the PRISMA guidelines, to understand the distribution of HHV-8 infection in Africa. More than two-thirds (64%) of studies reported on seroprevalence and 29.3% on genotypes; 9.5% were on both seroprevalence and genotypes. About 45% of African countries had data on HHV-8 seroprevalence exclusively, and more than half (53%) had data on either seroprevalence or genotypes. Almost half (47%) of the countries had no data on HHV-8 infection. There was high heterogeneity in the types of tests and interpretation algorithms used in determining HHV-8 seropositivity across the different studies. Generally, seroprevalence ranged from 2.0% in a group of young children in Eritrea to 100% in a small group of individuals with KS in Central African Republic, and in a larger group of individuals with KS in Morocco. Approximately 16% of studies reported on children. Difference in seroprevalence across the African regions was not significant (95% CI, 2 = 0.86; p = 0.35), although specifically a relatively significant level of infection was observed in HIV-infected children. About 38% of the countries had data on K1 genotypes. K1 genotypes A, A5, B, C, F and Z occurred at frequencies of 5.3%, 26.3%, 42.1%, 18.4%, 5.3% and 2.6%, respectively. Twenty-three percent of the countries had data for K15 genotypes, and genotypes P, M and N occurred at frequencies of 52.2%, 39.1%, and 8.7%, respectively. Data on HHV-8 inter-genotype recombinants in Africa are scanty. HHV-8 may be endemic in the entire Africa continent but there is need for a harmonized testing protocol for a better understanding of HHV-8 seropositivity. K1 genotypes A5 and B, and K15 genotypes P and M, from Africa, should be considered in vaccine design efforts DA - 2018-08-27 DB - ResearchSpace DP - Univen KW - HHV-8 KW - Seroprevalence KW - Genotypes KW - Systematic review KW - Africa LK - https://univendspace.univen.ac.za PY - 2018 T1 - HHV-8 Seroprevalence and Genotype Distribution in Africa, 1998–2017: A Systematic Review TI - HHV-8 Seroprevalence and Genotype Distribution in Africa, 1998–2017: A Systematic Review UR - http://hdl.handle.net/11602/2318 ER -