Mathebula, D.Garira, W.Makhuvha, Mulalo2019-06-052019-06-052019-05-18Makhuvha, Mulalo (2019) Multi-scale modelling of soil-transmitted Helminths infections in humans, University of Venda, South Africa.<http://hdl.handle.net/11602/1344>.http://hdl.handle.net/11602/1344MSc (Applied Mathematics)Department of Mathematics and Applied MathematicsIn this study, we develop a multiscale model of soil transmitted helminths in humans with a special reference to hookworm infection. Firstly, we develop a single scale model that comprises of five between host scale populations namely; susceptible humans, infected humans, eggs in the physical environment, noninfective worms in the physical environment and infective worms in the physical environment. Secondly, we extend the single scale model to incorporate within-host scales namely; infective larvae within-host, immature worms in small intestine, mature worm population and within-host egg population which resulted to a multiscale model. The models are analysed both numerically and analytically. The models are epidemiologically and mathematically well posed. Numerical simulation results show that there is a bidirectional relationship between the between-host and within-host scales. This is in agreement with the sensitivity analysis results, we noted that the same parameters that reduce reproductive number R0 are the same parameters that reduce the infective worms endemic equilibrium point. From the comparative effectiveness of hookworm interventions analysis results, we notice that any intervention combination that include wearing shoes controls and reduces the spread of the infection. The modelling framework developed in this study is vigorous to be applicable to other soil transmitted helminths infections1 online resource (viii, 106 leaves: color illustrations)enUniversity of VendaMultiscale modellingSoil-transmitted HelminthsUCTDHumansHookworm infectionInfections614. 552HelminthiasisHelminthsHookworm diseaseParasitesWormsHelminths -- HostsDissertationMakhuvha M. Multi-scale modelling of soil-transmitted Helminths infections in humans. []. , 2019 [cited yyyy month dd]. Available from: http://hdl.handle.net/11602/1344Makhuvha, M. (2019). <i>Multi-scale modelling of soil-transmitted Helminths infections in humans</i>. (). . Retrieved from http://hdl.handle.net/11602/1344Makhuvha, Mulalo. <i>"Multi-scale modelling of soil-transmitted Helminths infections in humans."</i> ., , 2019. http://hdl.handle.net/11602/1344TY - Dissertation AU - Makhuvha, Mulalo AB - In this study, we develop a multiscale model of soil transmitted helminths in humans with a special reference to hookworm infection. Firstly, we develop a single scale model that comprises of five between host scale populations namely; susceptible humans, infected humans, eggs in the physical environment, noninfective worms in the physical environment and infective worms in the physical environment. Secondly, we extend the single scale model to incorporate within-host scales namely; infective larvae within-host, immature worms in small intestine, mature worm population and within-host egg population which resulted to a multiscale model. The models are analysed both numerically and analytically. The models are epidemiologically and mathematically well posed. Numerical simulation results show that there is a bidirectional relationship between the between-host and within-host scales. This is in agreement with the sensitivity analysis results, we noted that the same parameters that reduce reproductive number R0 are the same parameters that reduce the infective worms endemic equilibrium point. From the comparative effectiveness of hookworm interventions analysis results, we notice that any intervention combination that include wearing shoes controls and reduces the spread of the infection. The modelling framework developed in this study is vigorous to be applicable to other soil transmitted helminths infections DA - 2019-05-18 DB - ResearchSpace DP - Univen KW - Multiscale modelling KW - Soil-transmitted Helminths KW - Humans KW - Hookworm infection KW - Infections LK - https://univendspace.univen.ac.za PY - 2019 T1 - Multi-scale modelling of soil-transmitted Helminths infections in humans TI - Multi-scale modelling of soil-transmitted Helminths infections in humans UR - http://hdl.handle.net/11602/1344 ER -