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Ramaite, I. D. I. Van Rhee, T. Ramonetha, Thata Golden 2015 2017-08-09T08:26:55Z 2017-08-09T08:26:55Z 2015-05 Ramonetha, T.G. 2015. Synthetic and spectroscopic studies of 6-substituted chromone derivatives. . . http://hdl.handle.net/11602/772 http://hdl.handle.net/11602/772 Ramonetha TG. Synthetic and spectroscopic studies of 6-substituted chromone derivatives. []. , 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11602/772 Ramonetha, T. G. (2015). <i>Synthetic and spectroscopic studies of 6-substituted chromone derivatives</i>. (). . Retrieved from http://hdl.handle.net/11602/772 Ramonetha, Thata Golden. <i>"Synthetic and spectroscopic studies of 6-substituted chromone derivatives."</i> ., , 2015. http://hdl.handle.net/11602/772 TY - Dissertation AU - Ramonetha, Thata Golden AB - See the attached abstract below DA - 2015-05 DB - ResearchSpace DP - Univen KW - Chromones KW - Synthesis KW - Bioactivity KW - Spectroscopy KW - Flash chromatography LK - https://univendspace.univen.ac.za PY - 2015 T1 - Synthetic and spectroscopic studies of 6-substituted chromone derivatives TI - Synthetic and spectroscopic studies of 6-substituted chromone derivatives UR - http://hdl.handle.net/11602/772 ER - Department of Chemistry MSc (Chemistry) Chromones and chromone derivatives are naturally occurring compounds found in the plant kingdom; for example, baicalein was used as a diuretic and anti-allergic drug in ancient Chinese medicine. A range of chromone-2-carboxylic acids were synthesized from six substituted 2- hydroxyacetophenones. From these chromone-2-carboxylic acids, the acid chlorides were synthesized, from which chromone-2-carboxamide derivatives such as N,N-dimethykhromone- 2-carboxamide, l-[(6-bromochromon-2-yl)-carbonyl]-pyrrolidine, 1-[(6-chlorochromon-2-yl)­ carbonyl]-pyrrolidine, l-[(6-methoxychromon-2-y1)-carbony1]-pyrrolidine, l-[(6-bromochromo- 2-yl)-carbonyl]-morpholine were also synthesized. The Suzuki cross-coupling reaction was also utilized, inserting a benzene ring in the chromone moiety of several chromone-2-carboxamides. The compounds synthesized were purified either by flash chromatography or recrystallization using ethanol-water. The yields of chromone-2-carboxylic acids ranged from 85-90 %, those of the chromone-2-carboxamides ranged from 40-72 %, and for the Suzuki reaction the yields ranged from 40-55 %. The compounds synthesized were analysed by I H and 13C nuclear magnetic resonance spectroscopy. The spectra of these compounds were as expected for the target compounds. The synthesized compounds were also analysed by FTIR spectroscopy for their functional groups, confirming the identities of the target compounds. 1 online resource(vii, 61 leaves): illustrations en PDF Chromones Synthesis Bioactivity Spectroscopy Flash chromatography UCTD 547.869 Spectrum analysis Organic cyclic compounds Heterocyclic compounds Flavonoids Plant pigments Pigments (Biology) Synthetic and spectroscopic studies of 6-substituted chromone derivatives Dissertation open.access