A putative HIV-1 subtype C/CRF11_cpx unique recombinant from South Africa

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dc.contributor.author Bessong, Obong Pascal
dc.contributor.author Iweriebor, Benson
dc.date.accessioned 2016-10-30T09:15:33Z
dc.date.available 2016-10-30T09:15:33Z
dc.date.issued 2016
dc.identifier.uri http://hdl.handle.net/11602/659
dc.description Publication of this article funded by HIV/AIDS and Global Health Research Programme, Department of Microbiology, University of Venda en_US
dc.description.abstract The HIV epidemic in South Africa is overwhelmingly driven by HIV-1 subtype C viruses. The HIV gag, pol, env (C2-V5) and nef sequences of virus 08MB26ZA, obtained from a 47 year old woman, were studied by phylogenetic analysis, REGA and the jumping Profile Hidden Markov Model (jPHMM) tools. The pol gene was further analyzed for recombination by Simplot. The pol and env sequences were examined for genetic drug resistance mutations and predicted co-receptor usage respectively. There was agreement in the assignment of the gag sequence as pure HIV-1 subtype C by phylogenetic, REGA and jPHMM analyses. The pol sequence clustered with CRF11_cpx and in the J-clade by phylogenetic analysis; and to a CRF11_cpx/subtype C recombinant by REGA. The assignment of pol to CRF11_cpx and subtype C was confirmed by Simplot. The recombinant was of the R5 biotype, with no important drug resistance mutations in the pol region. The epidemiologic and biologic significance of the virus are unknown. The finding suggests that complex viruses are being introduced into South Africa with potential implications for diagnosis. This is apparently the first report from South Africa of a putative unique recombinant involving CRF11_cpx and subtype C genomes. en_US
dc.language.iso en en_US
dc.publisher Springer en_US
dc.subject HIV-1 subtype C en_US
dc.subject CRF11-cpx en_US
dc.subject Recombinant en_US
dc.subject HIV subtyping en_US
dc.subject South Africa en_US
dc.title A putative HIV-1 subtype C/CRF11_cpx unique recombinant from South Africa en_US
dc.type Article en_US
dc.rights.holder Author's retain copyright

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