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Enteric pathogen co-infections in the paediatric population from rural communities in the Vhembe District, South Africa

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dc.contributor.author Ledwaba, S. E.
dc.contributor.author Kabue, J. P.
dc.contributor.author Barnard, T. G.
dc.contributor.author Traore, A. N.
dc.contributor.author Potgieter, N.
dc.date.accessioned 2022-11-09T07:53:26Z
dc.date.available 2022-11-09T07:53:26Z
dc.date.issued 2018-06-18
dc.identifier.citation Ledwaba, S. E., Kabue, J. P., Barnard, T. G., Traore, A. N. and Potgieter, N. Enteric pathogen co-infections in the paediatric population from rural communities in the Vhembe District, South Africa.S Afr J Child Health 2018;12(4):170-174. DOI:10.7196/SAJCH.2018.v12.i4.1550.<http://hdl.handle.net/11602/2334>.
dc.identifier.other DOI:10.7196/SAJCH.2018.v12.i4.1550.
dc.identifier.uri http://hdl.handle.net/11602/2334
dc.description.abstract Background. Enteric pathogens co-infections are a serious health risk in children under the age of 5 years. Objective. The study aimed to determine the prevalence of diarrhoea-causing pathogens in children suffering from diarrhoea in rural communities of the Vhembe District. Methods. A cross-sectional study was conducted from July 2014 to June 2015. Diarrhoeal stool specimens (N=237) were collected from children attending primary healthcare facilities in rural communities of the Vhembe District. Stools were screened for enteric viral adenovirus 40/41, rotavirus and norovirus pathogens by means of enzyme immuno-assay (EIA) and enteric bacterial Escherichia coli spp. (diarrhoeagenic pathotypes), Shigella spp., Salmonella spp. and Vibrio spp. pathogens by means of multiplex polymerase chain reaction. Results. A total of 59.1% (140/237) were positive for at least one or more enteric pathogens. Enterotoxigenic E. coli (ETEC) (27.9%), enteroaggregative E. coli (EAEC) (26.8%) and atypical enteropathogenic E. coli (EPEC) (17.9%) were frequently detected in children less than 2 years of age. Bacterial-bacteria co-infections were detected in 24.5% (n=58) and bacterial-viral co-infections in 14.3% (n=34) of the stool specimens. Conclusion. The findings indicated that enteric pathogen co-infections are major causes of diarrhoea in children less than 2 years of age in the Vhembe District. en_ZA
dc.description.sponsorship Water Research Commission (WRC) of South Africa (grant number K3/1750), the National Research Foundation (NRF), and the Research and Innovation Directorate of the University of Venda (registration number SMNS/14/MBY/28). C en_ZA
dc.language.iso en en_ZA
dc.title Enteric pathogen co-infections in the paediatric population from rural communities in the Vhembe District, South Africa en_ZA
dc.type Article en_ZA


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