Browsing Theses and Dissertations by Subject "Malaria -- Immunological aspects"

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Comparative analysis of a chimeric Hsp70 of E. coli and Plasmodium falciparum origin relative to its wild type forms

Lebepe, Charity Mekgwa (2019-05-18)

Sustaining proteostasis is essential for the survival of the cell and altered protein regulation leads to many cellular pathologies. Heat shock proteins (Hsps) are involved in the regulation of the protein quality control. ...
Establishment of interaction partners of Plasmodium falciparum heat shock protein 70-x(PfHsp 70-x)

Monyai, Florina Semakaleng (2018-05-18)

Plasmodium falciparum is a unicellular protozoan parasite that causes malaria in humans. The parasite is passed to humans through mosquito bites and migrates to the liver before it infects host erythrocytes. It is at the ...
Investigation of the role of the GGMP motif of Plasmodium falciparum Hsp70-1 on the chaperone function of the protein and its interaction with a co-chaperone, PfHop

Makumire, Stanley (2019-09-20)

The main malaria agent, Plasmodium falciparum expresses an Hsp70 (PfHsp70-1) which plays a significant role in parasite survival. PfHsp70-1 is distinct in that it possesses glycine-glycine-methionine-proline (GGMP) ...

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