Browsing Theses and Dissertations by Subject "Chaperone"

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Characterization of heat shock protein 70-z (PfHsp70-z) from plasmodium falciparium

Zininga, Tawanda (2015)

Malaria is a parasitic disease that accounts for more than 660 thousand deaths annually, mainly in children. Malaria is caused by five Plasmodium species P. ovale, P. vivax, P. malariae, P. falciparum and P. knowlesi. ...
Comparative analysis of a chimeric Hsp70 of E. coli and Plasmodium falciparum origin relative to its wild type forms

Lebepe, Charity Mekgwa (2019-05-18)

Sustaining proteostasis is essential for the survival of the cell and altered protein regulation leads to many cellular pathologies. Heat shock proteins (Hsps) are involved in the regulation of the protein quality control. ...
Elucidation of the role of the linker motifs of Plasmodium falciparum Hsp70-1 and Hsp70-z

Chakafana, Graham (2020-03-23)

The main malaria agent, Plasmodium falciparum, exhibits a complex life cycle. The parasite initially develops in a poikilothermic mosquito vector before it is subsequently transmitted to a homeothermic human host. As such, ...
Investigation of the role of the GGMP motif of Plasmodium falciparum Hsp70-1 on the chaperone function of the protein and its interaction with a co-chaperone, PfHop

Makumire, Stanley (2019-09-20)

The main malaria agent, Plasmodium falciparum expresses an Hsp70 (PfHsp70-1) which plays a significant role in parasite survival. PfHsp70-1 is distinct in that it possesses glycine-glycine-methionine-proline (GGMP) ...

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