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Browsing Department of Biochemistry and Microbiology by Author

Browsing Department of Biochemistry and Microbiology by Author "Zininga, T."

Now showing items 1-9 of 9

Biophysical characterization of KO513, a protein expressed in human invasive glioblastoma

Nemukondeni, Ndivhuwo (2020-06-26)

Glioblastoma multiforme (GBM) is the deadliest brain tumour. GBM is associated with poor prognosis, with its patients having a very short median survival and poor response to chemotherapy. GBM is a World Health Organization ...
Characterization of Plasmodium falciparum PFF1010c and screening of pyrimidine-quinoline hybrids as inhibitors of HsP70-HsP40 functional partnerships of the Malaria parasite

Mudau, Pertunia Thendo (2021-05)

With nearly half the world’s population at risk of malaria infection, 229 million new cases were recorded in 2019 with Sub-Saharan Africa accounting for most of these cases. In 2020, 384 000 malaria deaths were reported ...
Comparative analysis of a chimeric Hsp70 of E. coli and Plasmodium falciparum origin relative to its wild type forms

Lebepe, Charity Mekgwa (2019-05-18)

Sustaining proteostasis is essential for the survival of the cell and altered protein regulation leads to many cellular pathologies. Heat shock proteins (Hsps) are involved in the regulation of the protein quality control. ...
Elucidation of the role of the linker motifs of Plasmodium falciparum Hsp70-1 and Hsp70-z

Chakafana, Graham (2020-03-23)

The main malaria agent, Plasmodium falciparum, exhibits a complex life cycle. The parasite initially develops in a poikilothermic mosquito vector before it is subsequently transmitted to a homeothermic human host. As such, ...
Establishment of interaction partners of Plasmodium falciparum heat shock protein 70-x(PfHsp 70-x)

Monyai, Florina Semakaleng (2018-05-18)

Plasmodium falciparum is a unicellular protozoan parasite that causes malaria in humans. The parasite is passed to humans through mosquito bites and migrates to the liver before it infects host erythrocytes. It is at the ...
Exploration of interaction between Plasmodium falciparum Hsp70-x (PfHsp70-x) and human Hsp70-Hsp90 organizing protein (human Hop)

Mabate, Blessing (2017-09)

Malaria is a disease that claims about half a million lives annually, mainly children. There are 5 Plasmodium species that cause malaria; namely, P. falciparum, P. ovale, P. malariae, P. knowlesi and P. vivax. P. falciparum ...
In cellulo and biophysical exploration of the role of GGMP residues of Hsp70

Dongola, Tendamudzimu Harmfree (2022-07-15)

Hsp70 is a prominent molecular chaperone. Structurally, Hsp70 is composed of two domains, C-terminus substrate binding domain (SBD) and nucleotide binding domain (NBD). The NBD of Hsp70 is responsible for its ATPase ...
Investigation of the role of HSP70 in the uptake of Granzyme B by Malaria parasite-infected erythrocytes

Ramatsui, Lebogang (2019-09-20)

In 2017 malaria cases were estimated at 219 million and of these 435 000 resulted in death. Malaria is transmitted by female Anopheles mosquitoes which thrive in tropical and sub-tropical areas. Malaria is caused by five ...
Investigation of the role of the GGMP motif of Plasmodium falciparum Hsp70-1 on the chaperone function of the protein and its interaction with a co-chaperone, PfHop

Makumire, Stanley (2019-09-20)

The main malaria agent, Plasmodium falciparum expresses an Hsp70 (PfHsp70-1) which plays a significant role in parasite survival. PfHsp70-1 is distinct in that it possesses glycine-glycine-methionine-proline (GGMP) ...

Browsing Department of Biochemistry and Microbiology by Author "Zininga, T."

Browsing Department of Biochemistry and Microbiology by Author "Zininga, T."

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