Multi-scale modelling of soil-transmitted Helminths infections in humans

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dc.contributor.advisor Mathebula, D.
dc.contributor.advisor Garira, W.
dc.contributor.author Makhuvha, Mulalo
dc.date 2019
dc.date.accessioned 2019-06-05T10:43:18Z
dc.date.available 2019-06-05T10:43:18Z
dc.date.issued 2019-05-18
dc.identifier.citation Makhuvha, Mulalo (2019) Multi-scale modelling of soil-transmitted Helminths infections in humans, University of Venda, South Africa.<http://hdl.handle.net/11602/1344>.
dc.identifier.uri http://hdl.handle.net/11602/1344
dc.description MSc (Applied Mathematics) en_US
dc.description Department of Mathematics and Applied Mathematics
dc.description.abstract In this study, we develop a multiscale model of soil transmitted helminths in humans with a special reference to hookworm infection. Firstly, we develop a single scale model that comprises of five between host scale populations namely; susceptible humans, infected humans, eggs in the physical environment, noninfective worms in the physical environment and infective worms in the physical environment. Secondly, we extend the single scale model to incorporate within-host scales namely; infective larvae within-host, immature worms in small intestine, mature worm population and within-host egg population which resulted to a multiscale model. The models are analysed both numerically and analytically. The models are epidemiologically and mathematically well posed. Numerical simulation results show that there is a bidirectional relationship between the between-host and within-host scales. This is in agreement with the sensitivity analysis results, we noted that the same parameters that reduce reproductive number R0 are the same parameters that reduce the infective worms endemic equilibrium point. From the comparative effectiveness of hookworm interventions analysis results, we notice that any intervention combination that include wearing shoes controls and reduces the spread of the infection. The modelling framework developed in this study is vigorous to be applicable to other soil transmitted helminths infections en_US
dc.description.sponsorship NRF en_US
dc.format.extent 1 online resource (viii, 106 leaves: color illustrations)
dc.language.iso en en_US
dc.rights University of Venda
dc.subject Multiscale modelling
dc.subject Soil-transmitted Helminths
dc.subject Humans
dc.subject Hookworm infection
dc.subject Infections
dc.subject.ddc 614. 552
dc.subject.lcsh Helminthiasis
dc.subject.lcsh Helminths
dc.subject.lcsh Hookworm disease
dc.subject.lcsh Parasites
dc.subject.lcsh Worms
dc.subject.lcsh Helminths -- Hosts
dc.title Multi-scale modelling of soil-transmitted Helminths infections in humans en_US
dc.type Dissertation en_US

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