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Synthesis of 1, 3, 5 - Triazine Based Antimalarial Drugs

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dc.contributor.advisor Mnyakeni-Moleele, S. S.
dc.contributor.advisor Ramaite, I. D. I.
dc.contributor.author Mugwena, Dakalo Sandra
dc.date 2018
dc.date.accessioned 2018-10-04T05:25:37Z
dc.date.available 2018-10-04T05:25:37Z
dc.date.issued 2018-09-21
dc.identifier.uri http://hdl.handle.net/11602/1193
dc.description MSc (Chemistry)
dc.description Department of Chemistry
dc.description.abstract This dissertation focuses on the application of 1, 3, 5-triazine in a pharmaceutical point of view since it has wide range of uses as described in chapter 1. Malaria is one of the most prevalent and deadly infectious diseases worldwide though there are already many synthesized anti-malarial drugs which are in use presently, drug resistance seems to be one of the major problem and combination therapy seems to be the only solution for now. Hence in this study we used hybridization as a tool (Figure 9) to synthesize new antimalarial drugs using 1, 3, 5-triazine as an intermediate linker, linking known anti-malarial drug, different amine and chloroquine-like amines together using nucleophilic substitution reaction. As explained in chapter four of this dissertation, triazine is used to synthesize mono-, di- and tri-amino-1, 3, 5-triazine substituted products. Using THF as a solvent and K2CO3 as a base changing in temperatures, from 0 oC 25 oC or reflux. Some products were synthesized using microwave irradiation. The application of triazine as an intermediate linker in the above mentioned condition yielded five mono-amino substituted dichloro-1, 3, 5-triazine (21-25) in an average yield of 82%, three amino substitution chloro-1, 3, 5-triazine (26-28) in an average yield of 87%, two amino substituted-1, 3, 5-triazine (29, 30) in an average of 90%, nine chloroquine-like synthesized compounds (33-41) in 84 % average yields respectively. en_US
dc.description.sponsorship NRF en_US
dc.format.extent 1 online resource (vii, 69 leaves : color illustrations, color maps)
dc.language.iso en en_US
dc.rights University of Venda
dc.subject Malaria en_US
dc.subject Synthesis en_US
dc.subject Drugs en_US
dc.subject Triazine en_US
dc.subject Antimalarial en_US
dc.title Synthesis of 1, 3, 5 - Triazine Based Antimalarial Drugs en_US
dc.type Dissertation en_US

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